Gender differences in the association between insulin resistance assessed by estimated glucose disposal rate and the risk of all-cause and cardiovascular deaths in adults without diabetes
Authors' conclusion
Higher eGDR level was associated with lower risks of all-cause and cardiovascular deaths in a linear dose-response manner among non-diabetic females, while L-shaped relationships were observed among non-diabetic males.
Study context
- Population
- Non-diabetic adults, NHANES 1999–2018; deaths via National Death Index
- Participants
- 38,175 adults
- Exposure
- Estimated glucose disposal rate (eGDR) level and mortality, by sex
- Outcome
- All-cause and cardiovascular deaths
- Follow-up
- Median 9.8 years
Main finding
As reported in the abstract
- Males: L-shaped relationships; threshold points for all-cause and cardiovascular deaths (mg/kg/min)
- 8.50 and 8.49
- Males, left of threshold: eGDR and all-cause death, HR
- 0.91 (95% CI 0.88-0.94, P < 0.001)
- Males, left of threshold: eGDR and cardiovascular death, HR
- 0.87 (95% CI 0.82-0.93, P < 0.001)
- Males, after inflection point: increase in eGDR not related to lower risks of all-cause and cardiovascular deaths
- P > 0.05
Observational data: associations, not effects.
Original publication
Gender differences in the association between insulin resistance assessed by estimated glucose disposal rate and the risk of all-cause and cardiovascular deaths in adults without diabetes. Diabetes Res Clin Pract. Published 19 December 2024. doi:10.
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