Fructose intake from sugar-sweetened beverages is associated with a greater risk of hyperandrogenism in women: UK Biobank cohort study
Authors' conclusion
The consumption of ≥10 g/day fructose from SSB, corresponding to ≥200 mL serving, is associated with a 2% higher risk of hyperandrogenism in women. These observational data are supported by our genetic data.
Study context
- Population
- Participants of the UK Biobank (men and women)
- Exposure
- Fructose intake by source and rs2304681 A allele carriage
- Outcome
- Risk of hyperandrogenism (free androgen index >4.5); serum SHBG, total and free testosterone
Methodological detailspopulation-based cohort, UK Biobank
- Population-based cohort
- UK Biobank
Main finding
As reported in the abstract
Hyperandrogenism in women
Fructose from SSB (≥10 g/day): hyperandrogenism in women, OR
1.018
95% CI 1.010; 1.026
Observational data: associations, not effects.
Further findings
Genetic analysis: rs2304681 A allele carriers
- Biochemical hyperandrogenism (women), OR
- 0.997 (95% CI 0.955; 0.999)
- Acne vulgaris (men and women combined), OR
- 0.975 (95% CI 0.952; 0.999)
- Higher circulating sex hormone-binding globulin (SHBG) (men and women), lower serum free testosterone (women)
- Genetic study n = 383 392
Original publication
Fructose intake from sugar-sweetened beverages is associated with a greater risk of hyperandrogenism in women: UK Biobank cohort study. Eur J Endocrinol. Published 30 January 2024. doi:10.
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