Frequency and impact of musculoskeletal symptoms on quality of life in MEN2B
Authors' conclusion
We report a high prevalence of musculoskeletal-related complaints in MEN2B which significantly affects QOL. This suggests a need to provide better holistic care including a multidisciplinary team with physiotherapist, orthopaedic and dental specialist input.
Study context
- Population
- Patients with MEN2B (Association for Multiple Endocrine Neoplasia Disorders (AMEND) members and worldwide social media group)completed survey
- Participants
- 48 patients
- Outcome
- MSK-related symptoms and impact on QOL
Methodological detailsonline survey, distributed by AMEND and via social media group
- Online survey
- Distributed by AMEND and via social media group
Main finding
As reported in the abstract
- Musculoskeletal (MSK) weakness
- 73% (n = 35)
- Pain
- 58% (n = 28)
- Median pain score (IQR)
- 7 (5-8)
- Pain daily
- 44% (n = 15)
- Pain constant
- 21% (n = 7)
- Physique 'different'
- 63% (n = 30)
- Marfanoid body features
- 40% (n = 19)
- Scoliosis
- 70% (n = 16)
- Pes cavus
- 63% (n = 22)
- Dental problems
- 69% (n = 33)
- Interdental spacing
- 61% (n = 20)
- Median impact of MSK symptoms on quality of life (QOL) (IQR)
- 6 (3-9)
- Highest impact: structural deformities
- 53% (n = 18)
- Highest impact: pain
- 26% (n = 9)
Observational data: associations, not effects.
Original publication
Frequency and impact of musculoskeletal symptoms on quality of life in MEN2B. Clin Endocrinol (Oxf). Published 4 October 2022. doi:10.
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