Free T4 Age-Specific Reference Intervals from Birth to the 10 th Decade of Life Using Direct Dialysis
Authors' conclusion
The development and validation of FT4 RIs provides interpretive criteria for FT4 results for patients throughout the lifespan.
Study context
- Population
- Individuals aged 0 days to 100 years with specimens submitted for routine free thyroxine (FT4) testing by direct dialysis at a commercial reference laboratory; de-identified retrospective resultsFT4 results
- Participants
- 1,862,273 individuals
- Outcome
- Age-specific FT4 reference intervals from birth to age 100
Methodological detailsmulti-modal decomposition (MMD) analysis, direct dialysis, commercial reference laboratory, validated in a separate data set, Intervals validated using a separate data set
- Multi-modal decomposition (MMD) analysis
- Direct dialysis
- Commercial reference laboratory
- Validated in a separate data set
- Intervals validated using a separate data set
Main finding
As reported in the abstract
Age-specific FT4 RIs
Distinct reference intervals (RIs) by age
14
Observational data: associations, not effects.
Original publication
Free T4 Age-Specific Reference Intervals from Birth to the 10 th Decade of Life Using Direct Dialysis. Thyroid. Published 3 November 2025. doi:10.
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