Fracture risk and treatment thresholds in patients with diabetes
Authors' conclusion
Compared to individuals without diabetes, fracture risk was increased in patients with T1D and T2D independent of BMD. Our study suggests that the T-score thresholds for treatment initiation in T1D and T2D should be increased.
Study context
- Population
- Cases with first incident major osteoporotic fracture within 2 years before or 1 year after a DXA, and fracture-free matched controls; National Danish Registries (DXA 2000–2019)17,703 cases · 17,703 controls
- Comparison
- T1D and T2D vs no diabetes
- Outcome
- T-score thresholds in T1D and T2D with fracture risk equivalent to that of individuals without diabetes and a T-score of −2.5
Methodological detailsmatched on age, gender and time period of DXA, logistic regression
- Matched on age, gender and time period of DXA
- Logistic regression
Main finding
As reported in the abstract
Total hip T-score with major osteoporotic fracture (MOF) risk equivalent to no diabetes at T-score −2.5
T1D
−1.4
T2D
−2.1
Observational data: associations, not effects.
Further findings
| Outcome | OR (95 % CI) | |
|---|---|---|
| Risk of MOF, adjusted for hip BMDT1Dvs No diabetes | 1.8 (1.4–2.3) | |
| Risk of MOF, adjusted for hip BMDT2Dvs No diabetes | 1.2 (1.1–1.3) | |
| 0.512Odds ratio (log scale) |
| Outcome | T1D | T2D |
|---|---|---|
| T-score with hip fracture risk equivalent to no diabetes at T-score −2.5 | −1.9 | −1.6 |
Femoral neck and lumbar spine BMD
- Similar findings apply for femoral neck and lumbar spine BMD
Original publication
Fracture risk and treatment thresholds in patients with diabetes. Diabetes Metab. Published 7 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →