Fracture Incidence in Graves' Disease: A Population-Based Study
Authors' conclusion
There were no significant differences in total fracture rate between GD and the general population. However, men older than 52 years had a higher vertebral fracture rate. This study also shows that patients with treated GD receive more osteoporosis treatments compared to the general population.
Study context
- Population
- Patients with incident graves' disease (GD) and matched controls, Sweden, included 16–18 years after diagnosismatched cohort
- Participants
- 2,134 vs 21,261
- Exposure
- GD vs matched controls
- GDn = 2,134
- Controlsn = 21,261reference
- Outcome
- Fracture risk
Methodological detailspopulation-based, age-, sex- and county-matched controls, Swedish national drug and patient registries
- Population-based
- Age-, sex- and county-matched controls
- Swedish national drug and patient registries
Main finding
As reported in the abstract
Fracture rates
- No significant differences in fracture rates between GD and controls
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Vertebral fracture rate, men aged >52 yearsAdjusted for comorbidities; higher with GD · after adjustment for comorbidities | 2.83 (1.05–7.64) | |
| 0.10.31310Hazard ratio (log scale) |
Osteoporosis and corticosteroid treatment
- Rates of osteoporosis treatments and corticosteroid treatment higher with GD
- HR for GD–fracture association largely unchanged after adjustment for osteoporosis and corticosteroid treatments
Original publication
Fracture Incidence in Graves' Disease: A Population-Based Study. Thyroid. Published 19 October 2023. doi:10.
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