Associations Between Physical Activity and the Risk of Hip Fracture Depending on Glycemic Status: A Nationwide Cohort Study
Authors' conclusion
Higher PA levels are associated with a lower risk of HF. This protective effect of PA on fracture risk is greatest in patients with DM, particularly in those with DM of 5 years or greater.
Study context
- Population
- Patients older than 50 without T1D or past fractures. Glycemic strata: normal glucose tolerance, impaired fasting glucose, new-onset T2D, T2D <5 years, T2D ≥5 years. Physical activity (PA) assessed by the Korean adaptation of the International Physical Activity Questionnaire Short Form
- Participants
- 3,723,097 participants
- Exposure
- Physical activity levels, by glycemic status
- Outcome
- Incident hip fracture
Methodological detailsCox proportional hazard regression, adjusted
- Cox proportional hazard regression
- Adjusted
Main finding
As reported in the abstract
Hip fracture risk by PA level
- Highest hip fracture risk with the lowest PA level (<500 MET-min/wk)
- Similar risks across MET 500 to 1000, 1000 to 1500 and >1500 categories, with variations across glycemic status groups; exceptions notably in women with normoglycemia
Observational data: associations, not effects.
Further findings
Hip fracture risk by PA level in T2D ≥5 years
- aHR in men vs reference (PA <500 MET-min/wk within T2D ≥5 years)
- 0.74 (0.62-0.88)
- aHR in women vs reference (PA <500 MET-min/wk within T2D ≥5 years)
- 0.74 (0.62-0.89)
- Consistent inverse pattern, with few exceptions, in men and women with T2D ≥5 years; benefit of PA most evident in this group
- Comparator PA category not stated in the abstract
Original publication
Associations Between Physical Activity and the Risk of Hip Fracture Depending on Glycemic Status: A Nationwide Cohort Study. J Clin Endocrinol Metab. Published 18 October 2023. doi:10.
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