Bone strain index for fracture risk assessment in older men—the prospective STRAMBO study
Main finding · Fracture risk per SD increase in trochanter BSIResult — go to the resultHazard ratio 1.34 95% CI 1.14–1.58Authors' conclusion
The BSI at both the lumbar and the femoral sites was associated with a higher fracture risk independently of FRAX and prior falls in older men followed prospectively for 12 years.
Study context
- Population
- Men aged ≥60, followed up for 12 years; lumbar spine and hip BMD, bone strain index (BSI), FRAX for major osteoporotic fractures (MOPFx) and lumbar spine trabecular bone score (TBS) assessed at baseline159 men had 198 incident fractures
- Participants
- 825 participants
- Exposure
- Higher vs lower bone strain index
- Outcome
- Incident fracture risk
- Follow-up
- 12 years
Main finding
Fracture risk per SD increase in trochanter BSI
Hazard ratio
1.34
95% CI 1.14–1.58
P < 0.001
Trochanter BSI, per SD increase
HR 1.34 (95% CI 1.14–1.58); P < 0.001
Per SD increase, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| MOPFx prediction, TBS and trochanter BSI analysed jointlyTBS, per SD decrease | 1.38 (1.04–1.84) | P < 0.05 | |
| MOPFx prediction, TBS and trochanter BSI analysed jointlyTrochanter BSI, per SD increase | 1.49 (1.16–1.91) | P < 0.005 | |
| 0.512Hazard ratio (log scale) |
MOPFx prediction, TBS and trochanter BSI analysed jointly
- Contributions of TBS and BSI varied according to fracture and BSI site
Original publication
Bone strain index for fracture risk assessment in older men—the prospective STRAMBO study. Eur J Endocrinol. Published 28 November 2024. doi:10.
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