Choose your mother wisely: the familial resemblance of bone adaptation
Authors' conclusion
Our results suggest that phenotype membership in females changes with age in a pattern that is consistent with the stages of osteoporosis. Additionally, we showed familial resemblance in bone phenotype, which can be used to predict bone adaptations between mothers and daughters that are associated with bone loss with aging.
Study context
- Population
- Biological mother and daughter pairs; bone phenotype membership to three pre-defined phenotypes (healthy, low volume, low density)
- Participants
- 101 mother–daughter pairs
- Outcome
- Bone phenotype trajectory with age and familial resemblance
Methodological detailsmother–daughter pairs, high resolution peripheral quantitative computed tomography, Linear regression models assessed familial resemblance in mother-daughter pairs
- Mother–daughter pairs
- High resolution peripheral quantitative computed tomography
- Linear regression models assessed familial resemblance in mother-daughter pairs
Main finding
As reported in the abstract
Familial resemblance (½h2), healthy phenotype
β = 0.432
p < 0.01
Mother–daughter association in phenotype membership, healthy (adjusted for age, height, weight)
R2 = 0.347
p = 0.04
Mother–daughter association in phenotype membership, low volume (adjusted for age, height, weight)
R2 = 0.416
p < 0.01
Observational data: associations, not effects.
Original publication
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