A Four‐Week Treatment With Dapagliflozin Is Associated With a Reduction in Insulin‐Stimulated Renal Cortical Glucose Uptake: A Post Hoc Analysis From a Pilot Study
Authors' conclusion
Although the primary between-group comparison did not reach statistical significance, likely due to the limited sample size (n = 7 per group), a consistent directional pattern was observed across all renal SUV parameters, with reductions in the dapagliflozin group and stable or slightly increased values in the placebo group. These findings suggest decreased glucose uptake in an insulin-stimulated state (HEC) in the dapagliflozin group.
Study context
- Population
- Patients with T2D, stable coronary artery disease and preserved glomerular filtration rates
- Participants
- 7 vs 7
- Comparison
- Dapagliflozin 10 mg daily vs placebo for 4 weeks
- Dapagliflozinn = 7
- Placebon = 7reference
- Primary endpoint
- Between-group change in renal cortical [18F]-FDG uptake (SUV parameters) on PET during hyperinsulinemic-euglycemic clamp
- Follow-up
- 4 weeks
Methodological detailssingle-centre, prospective, double-blind, pilot study
- Single-centre
- Prospective
- Double-blind
- Pilot study
Primary result
As reported in the abstract
Change from baseline in renal SUV parameters, between groups
- Between-group comparison (Mann-Whitney U test on change-from-baseline values) did not reach statistical significance for any standardised uptake value (SUV) parameter
- Consistent directional pattern across all renal SUV parameters: reductions with dapagliflozin, stable or slightly increased values with placebo
Further findings
| Outcome | P value |
|---|---|
| Within-group change in renal SUV_peak · 4 weeksSignificant reduction | P = 0.028 |
Within-group change in renal SUV_peak · 4 weeks
- No significant change in SUV_peak in the placebo group
Original publication
A Four‐Week Treatment With Dapagliflozin Is Associated With a Reduction in Insulin‐Stimulated Renal Cortical Glucose Uptake: A Post Hoc Analysis From a Pilot Study. Diabetes Obes Metab. Published 23 June 2026. doi:10.
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