FGFR Alterations in Thyroid Carcinoma: A Novel Class of Primary Drivers with Significant Therapeutic Implications and Secondary Molecular Events Potentially Mediating Resistance in Thyroid Malignancy
Authors' conclusion
This study presents the first description of a collection of thyroid carcinomas grouped by primary driver alterations in FGFR, as well as a cohort of thyroid tumors with secondary alterations that potentially lead to tumor progression or resistance to targeted therapy.
Study context
- Population
- Sequenced thyroid malignancies with pathogenic alterations in the FGFR gene family, queried from molecular data of each center17 with FGFR alterations
- Participants
- 5,030 participants
- Exposure
- FGFR primary driver vs FGFR secondary alteration
- FGFR primary drivern = 11
- FGFR secondary alterationn = 6
- Outcome
- FGFR alterations in sequenced thyroid malignancies
Main finding
As reported in the abstract
- Tumors with FGFR alterations
- 17
- FGFR as primary molecular driver
- 11
- FGFR as secondary pathogenic alteration
- 6
- Primary drivers: gene fusions (FGFR2:VCL 4, TG::FGFR1 3, FGFR2::CIT, FGFR2::SHTN1)
- 9
- Primary drivers: FGFR1 amplification
- 2
- Secondary alterations: canonical driver present / no clear primary driver
- 5 / 1
Observational data: associations, not effects.
Original publication
FGFR Alterations in Thyroid Carcinoma: A Novel Class of Primary Drivers with Significant Therapeutic Implications and Secondary Molecular Events Potentially Mediating Resistance in Thyroid Malignancy. Thyroid. Published 7 August 2024. doi:10.
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