Low-invasive somatic oncogenes and lymph node metastasis in pediatric papillary thyroid cancer: implications for prophylactic central neck dissection
Authors' conclusion
Pediatric patients with low-invasive somatic oncogenic alterations are at low risk for metastasis to central neck LNs. Our findings suggest that preoperative knowledge of somatic oncogene alterations provides objective data to stratify pediatric patients who may not benefit from pCND.
Study context
- Population
- Pediatric patients with PTC who underwent somatic oncogene testing post thyroidectomy, July 2003–July 2022
- Participants
- 192 eligible PTC patients
- Exposure
- Low-invasive vs high-invasive somatic oncogenic alterations
- Low-invasive alterationsn = 19
- High-invasive alterationsn = 128reference
- Outcome
- Lymph node (LN) metastasis (central neck)
Main finding
As reported in the abstract
LN metastasis
P < 0.001
Observational data: associations, not effects.
Further findings
Malignant preoperative cytology
P < 0.001
LNs dissected from central neck
- Malignant preoperative cytology: denominators 18 and 124
High-invasive alteration type
- BRAFV600E
- 45/192, 23%
- Oncogenic fusion
- 83/192, 43%
Original publication
Low-invasive somatic oncogenes and lymph node metastasis in pediatric papillary thyroid cancer: implications for prophylactic central neck dissection. Eur Thyroid J. Published 2 August 2024. doi:10.
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