Familial Associations of Metabolic Syndrome and Its Interrelated Traits in Southwestern Indigenous Americans
Authors' conclusion
Parental MetS characteristics were significantly associated with T2D and cardiometabolic risk factors in offspring. Associations were stronger during adolescence and between maternal-offspring pairs. These findings strongly support the need for family-based interventions directed at modifying health behaviors in high-risk population groups.
Study context
- Population
- Mother-father-offspring triads (offspring aged 5–19 years) in an Indigenous community in Arizona, longitudinal study 1965–2007; parental metabolic syndrome (MetS) by modified Adult Treatment Panel III criteria
- Participants
- 1,255 mother-father-offspring triads
- Exposure
- Offspring of parents with vs without MetS components
- Outcome
- Associations of MetS components between spouses and between parents and offspring
Methodological detailsfamily-based (mother-father-offspring triads), within a longitudinal study
- Family-based (mother-father-offspring triads)
- Within a longitudinal study
Main finding
As reported in the abstract
Parent-offspring associations of MetS components
Difference in offspring fasting glucose
10.3 mg/dL
offspring ages 12 to 19 years
Difference in offspring fasting glucose
2.61 mg/dL
offspring ages 5-11 years
Observational data: associations, not effects.
Further findings
- Significant spousal concordance in metabolic risk attributes
Original publication
Familial Associations of Metabolic Syndrome and Its Interrelated Traits in Southwestern Indigenous Americans. J Clin Endocrinol Metab. Published 3 May 2025. doi:10.
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