Factors that determine glucose variability, defined by the coefficient of variation in continuous glucose monitoring values, in a Chinese population with type 2 diabetes
Authors' conclusion
Our study suggests that impaired pancreatic β-cell function may be a clinical determining factor of CV of glucose in people with T2DM.
Study context
- Population
- Chinese subjects with T2D; Continuous glucose monitoring (CGM)-derived coefficient of variation (CV) of glucose; β-cell function by C-peptide after 100-g steamed bun meal test
- Participants
- 716 subjects
- Outcome
- Clinical determinants of CV of glucose (β-cell function)
Main finding
As reported in the abstract
Determinants of glucose CV
- C-peptide (Cp0h–Cp3h), AUC-Cp0.5h and AUC-Cp3h decreased with increasing CV quartile
- P < 0.05
- CV negatively correlated with HOMA-β, C-peptide at all timepoints, AUC-Cp0.5h and AUC-Cp3h
- P < 0.001
- Per 1-unit increase in AUC-Cp0.5h, risk of unstable glucose homeostasis (CV > 36%), adjusted multinomial logistic regression: OR 0.683 (95% CI 0.478-0.976); 31.7% reduction
- P = 0.036
Observational data: associations, not effects.
Further findings
Cut-off values predicting unstable glucose homeostasis (CV >36%)
ng/mL
- AUC-Cp0.5h cut-off
- 0.735
- AUC-Cp3h cut-off
- 13.355
Original publication
Factors that determine glucose variability, defined by the coefficient of variation in continuous glucose monitoring values, in a Chinese population with type 2 diabetes. Diabetes Obes Metab. Published 12 November 2023. doi:10.
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