Factors influencing traditional adiposity indicators and mammary adipocyte size in women with breast cancer
Authors' conclusion
While excess adiposity is a complex condition that cannot be attributed to a single factor, menopausal status seems to be the main determinant of excess adiposity in women with breast cancer and the only independent determinant of mammary adipocyte size. Among lifestyle factors, ever smoking was the strongest independent determinant of higher adiposity, followed by high intakes of fats, particularly animal fats. If targeted efficiently, some of these modifiable factors could reduce the burden among breast cancer patients.
Study context
- Population
- Consecutive women with breast cancer, biobank of a breast cancer reference center
- Participants
- 160 consecutive patients
- Outcome
- Associations of modifiable factors with traditional adiposity indicators (anthropometric indices) and mammary adipocyte size
Methodological detailsconsecutive patients, biobank of a breast cancer reference center, directed acyclic graph, principal component analysis of dietary intakes, robust univariate and multivariable linear regression
- Consecutive patients
- Biobank of a breast cancer reference center
- Directed acyclic graph
- Principal component analysis of dietary intakes
- Robust univariate and multivariable linear regression
Main finding
As reported in the abstract
- Menopausal status, ever smoking, tumour grade and higher weight at 18 years consistently associated with higher adiposity
- Higher animal fat intake consistently associated with higher body mass index (BMI)
- High educational attainment consistently associated with lower BMI and waist-to-height ratio
- Higher physical activity associated with lower adiposity and adipocyte cell size, and higher age with higher adiposity and adipocyte cell size, only in univariate models
- Only menopausal status consistently associated with higher mammary adipocyte size
Observational data: associations, not effects.
Original publication
Factors influencing traditional adiposity indicators and mammary adipocyte size in women with breast cancer. Int J Obes (Lond). Published 29 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →