Lack of fibro-inflammatory response in human mammary adipose tissue in obesity
Authors' conclusion
Obesity is not associated with inflammation nor fibrosis in MAT, highlighting its unique behavior.
Study context
- Population
- Women undergoing mastectomy for breast cancer risk reduction or treatment; tumor-free mammary adipose tissue (MAT)
- Participants
- 96 women
- Exposure
- Women with obesity vs lean women
- Obesityn = 43
- Leann = 53reference
- Outcome
- Markers of adipose tissue dysfunction (immune cell infiltration, secretion pattern and fibrosis) in tumor-free MAT
Main finding
As reported in the abstract
Markers of MAT dysfunction
- Increase of CD206+/HLA-DR+ macrophages in stromal vascular fraction of MAT with obesity vs lean
- Other immune cell infiltration and endothelial or adipose progenitor cell numbers similar between groups
- No heightened secretion of pro-inflammatory cytokines, TGF-β1 or MCP-1 with obesity
- Absence of fibrosis; slightly reduced collagen secretion and deposition in MAT with obesity vs lean
Observational data: associations, not effects.
Further findings
Bulk transcriptomics of CD206+ macrophages
- Significant decrease in extra-cellular matrix (ECM) component expression and processing in obesity
Original publication
Lack of fibro-inflammatory response in human mammary adipose tissue in obesity. Int J Obes (Lond). Published 29 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →