Exploring the Role of Taste Receptors (TAS2Rs) in Obesity: Insights From Human and Rat Models
Authors' conclusion
Intestinal TAS2Rs may influence metabolic regulation and bariatric surgery outcomes, suggesting their potential as therapeutic targets in female obesity. Further studies should clarify their underlying mechanisms.
Study context
- Population
- Female rats fed a cafeteria diet for 17 weeks; women with class III obesity, with or without metabolic syndrome (MS), undergoing RYGB
- Comparison
- Cafeteria diet vs control in rats; jejunal TAS2R expression vs weight loss after RYGB in women with or without MS
- Outcome
- Intestinal TAS2R expression and weight loss after RYGB
- Follow-up
- 12 months postsurgery
Methodological detailshuman and rat models
- Human and rat models
Main finding
As reported in the abstract
12 months postsurgery
- In rats, cafeteria diet significantly reduced Tas2r expression, especially in jejunum and duodenum
- Women with MS: higher TAS2R13 and TAS2R20 expression correlated with greater weight loss after RYGB
- Women without MS: higher TAS2R5 expression showed similar associations
- TAS2R expression strongly linked to surgical outcomes
- In rats, Tas2r108 (ileum) and Tas2r144 (jejunum) expression differed between obese and lean animals
Original publication
Exploring the Role of TAS2Rs in Obesity: Insights From Human and Rat Models. Obesity (Silver Spring). Published 26 October 2025. doi:10.
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