Memory Performance and Hippocampal Volumes in Healthy Weight Children at High‐ and Low‐Familial Risk for Obesity
Authors' conclusion
Memory and hippocampal volume differences may reflect underlying familial risk of OW/OB in HW children.
Study context
- Population
- Healthy weight children aged 8–11, classified by parental weight status
- Participants
- 95 children
- Exposure
- Healthy weight (HW) children at high vs low familial risk for OW/OB
- HRn = 43
- Low risk (LR)n = 52reference
- Outcome
- Memory performance (VLLT-Food-C; Child Memory Scale word pairs, dot locations) and hippocampal and subfield (CA1, CA3, DG, subiculum) volumes on MRI
Main finding
As reported in the abstract
- LR vs HR · VLLT-Food-C short-delay cued recall; better in LR
- β 0.34; P < 0.01
- LR vs HR · VLLT-Food-C long-delay cued recall; better in LR
- β 0.21; P = 0.04
- LR vs HR · Word pairs delayed recall; better in LR
- β 0.21; P = 0.04
- Between HR and LR · Right dentate gyrus (DG) volume after intracranial volume adjustment; smaller in HR
- β 0.15; P = 0.04
- HR had smaller bilateral whole hippocampus, CA1, DG and right CA3 volumes
- ps < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| BMIHR > LR | P = 0.003 |
BMI
- Groups did not differ on demographics except BMI
Original publication
Memory Performance and Hippocampal Volumes in Healthy Weight Children at High‐ and Low‐Familial Risk for Obesity. Pediatr Obes. Published 26 October 2025. doi:10.
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