Exogenous Glucagon-like Peptide 2 Counteracts Exogenous Cholecystokinin-induced Gallbladder Contraction in Healthy Men
Authors' conclusion
Exogenous GLP-2 counteracts exogenous CCK-induced gallbladder emptying in healthy men, pointing to a possible therapeutic potential for GLP-2 as a relaxing modulator of gallbladder smooth muscle tone (eg, as a bridge to surgery in biliary colic). The effect may also explain the gallbladder-related adverse events reported for GLP-2 receptor agonists used in the treatment of short bowel syndrome.
Study context
- Population
- Healthy men in the fasted state; mean (SD) age 24.7 (3.6) years, BMI 22.9 (1.6) kg/m²4 experimental days each
- Participants
- 15 men
- Comparison
- GLP-2 vs placebo infusion, with and without CCK infusion
- Primary endpoint
- Gallbladder volume measured by ultrasonography
- Follow-up
- Baseline and throughout the 4-hour study day
Methodological detailsdouble-blind, placebo-controlled, crossover
- Double-blind
- Placebo-controlled
- Crossover
Primary result
As reported in the abstract
Gallbladder volume · throughout 4-hour study day
- GLP-2 + placebo did not affect gallbladder volume vs placebo + placebo
- Combined with CCK, GLP-2 completely abolished the strong gallbladder-contracting effect seen with CCK + placebo, restoring baseline gallbladder volume
Original publication
Exogenous Glucagon-like Peptide 2 Counteracts Exogenous Cholecystokinin-induced Gallbladder Contraction in Healthy Men. J Clin Endocrinol Metab. Published 18 June 2024. doi:10.
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