Obesity

Exercise-induced Changes in Central Adiposity During an RCT: Effect of Exercise Dose and Associations With Compensation

J Clin Endocrinol MetabPublished Secondary analysis of a randomised controlled trial

Authors' conclusion

In the presence of significant weight compensation, exercise at doses recommended for health and weight loss and weight maintenance leads to negligible changes in central adiposity.

Study context

Population
Adults with overweight or obesity (mean ± SD BMI 31.5 ± 4.7 kg/m²)randomized
Participants
170 adults
Comparison
Exercise at 8 KKW or 20 KKW vs control
Primary endpoint
Change in central adiposity (waist circumference; VAT by DXA)
Follow-up
6 months
Methodological detailsancillary analysis, 6-month
  • Ancillary analysis
  • 6-month

Primary result

As reported in the abstract

Change in waist circumference

Control

.0

95% CI −1.0–1.0 · cm

8 KKW

−.7

95% CI −1.7 to .4 · cm

20 KKW

−1.3

95% CI −2.4 to −.2 · cm

P ≥ 0.23

Further findings

OutcomeIncrease (cm) (95% CI)P value
Change in waist circumference: exercisers who compensatedvs those who did not · 6 months2.5 (.8 to 4.2)P < 0.01
OutcomeIncrease (kg) (95% CI)P value
Change in VAT: exercisers who compensatedvs those who did not · 6 months.23 (.14 to .31)P < 0.01

Weight compensation (weight loss less than expected) among exercisers · 6 months

Exercisers who compensated
82.6%

Desire to eat as predictor of visceral adipose tissue (VAT) change during exercise

β
.21
P
P = 0.03

Original publication

Exercise-induced Changes in Central Adiposity During an RCT: Effect of Exercise Dose and Associations With Compensation. J Clin Endocrinol Metab. Published 29 November 2023. doi:10.1210/clinem/dgad696

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