Exercise and diet effects on delay discounting and related neurobiology in adults with overweight or obesity: A randomized trial
Authors' conclusion
Both interventions altered delay discounting behaviors. Exercise training was associated with reduced fed-state engagement of brain regions involved in self-referential processing and regulation during decision-making.
Study context
- Population
- Adults with overweight or obesity
- Participants
- 40 adults
- Comparison
- Exercise training vs diet intervention
- Primary endpoint
- Fasted-fed intervention effects on delay discounting propensity (k) and brain response in regions of interest (medial prefrontal cortex, anterior cingulate cortex, bilateral anterior insulae) during functional magnetic resonance imaging (fMRI) delay discounting task
- Follow-up
- Baseline to postintervention (12 weeks)
Primary result
As reported in the abstract
Delay discounting (k), reaction time and weight, across groups · baseline to postintervention
- Across groups, k and reaction time during delay discounting decreased and weight decreased
- p values ≤ 0.010
Further findings
Exploratory fed-state whole-brain analysis: right dorsolateral prefrontal cortex response
- Group × session effect, driven by exercise-associated changes
- P < 0.005
- Exploratory
Fed-state anterior cingulate cortex response
- Group × session interaction effect, driven by reductions in fed-state response
- P = 0.006
Original publication
Exercise and diet effects on delay discounting and related neurobiology in adults with overweight or obesity: A randomized trial. Obesity (Silver Spring). Published 19 May 2025. doi:10.
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