Exclusive association of non-HDL/HDL ratio with albuminuria in diabetes and its nonlinear pattern in advanced chronic kidney disease (CKD): Findings from NHANES 2015–2020
Authors' conclusion
NHHR associates with albuminuriaexclusively in diabetesand exhibits anonlinear pattern in CKD stage 3. These findings indicate diabetes-specific renal injury patterns and CKD stage-dependent pathophysiological mechanisms.
Study context
- Population
- US adults aged 20–70 years with eGFR ≥ 30 mL/min/1.73 m², NHANES 2015–2020
- Participants
- 10,613 adults
- Outcome
- Association between non-HDL/HDL cholesterol ratio (NHHR) and urinary albumin-to-creatinine ratio (UACR)
Main finding
As reported in the abstract
UACR per 1-unit NHHR increase
Overall: Urinary albumin-to-creatinine ratio (UACR) increase per 1-unit NHHR increase
4.46 mg/g
95% CI 1.13–7.78P = 0.009
Diabetics: β
23.56 mg/g
95% CI 8.59–38.54P < 0.001
Observational data: associations, not effects.
Further findings
Nonlinearity of NHHR-UACR association by CKD stage
- Stage 1: linear relationship
- P = 0.426
- Stage 2: marginal nonlinearity
- P = 0.031
- Stage 3: markedly nonlinear, accelerated UACR increase beyond NHHR of ≈3.5
- P < 0.001
Effect modification
- Ethnicity: stronger in Non-Hispanic Blacks
- P = 0.016
- Sex: greater in females
- P = 0.048
Original publication
Exclusive association of non-HDL/HDL ratio with albuminuria in diabetes and its nonlinear pattern in advanced CKD: Findings from NHANES 2015–2020. Diabetes Res Clin Pract. Published 11 February 2026. doi:10.
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