Distinct microRNA signatures in Platelet-Rich Plasma-Derived extracellular vesicles predict healing outcomes in chronic diabetic foot ulcers
Authors' conclusion
The intrinsic miRNA composition of PRP-EVs is a critical determinant of PRP therapeutic efficacy. miR-20a-5p and miR-21-5p serve as negative predictive biomarkers, whereas miR-223-3p indicates a favorable prognosis. Profiling these miRNAs offers a novel approach for PRP quality control and personalized regenerative strategies.
Study context
- Population
- Patients with refractory diabetic foot ulcers (DFUs)
- Participants
- 10 patients
- Outcome
- Clinical wound closure
- Follow-up
- 6 weeks
Methodological detailssingle-group, in vitro keratinocyte migration assay
- Single-group
- In vitro keratinocyte migration assay
Main finding
As reported in the abstract
Wound closure rate · week 6
Platelet-rich plasma (PRP)
≈90%
average
Observational data: associations, not effects.
Further findings
PRP-EV microRNA (miRNA) expression and healing
- miRNA expression showed substantial heterogeneity
- High miR-20a-5p and miR-21-5p in PRP-EVs significantly associated with delayed clinical healing and impaired keratinocyte migration
- Elevated miR-223-3p correlated with accelerated wound closure
Original publication
Distinct microRNA signatures in Platelet-Rich Plasma-Derived extracellular vesicles predict healing outcomes in chronic diabetic foot ulcers. Diabetes Res Clin Pract. Published 4 February 2026. doi:10.
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