Evolution of cardiovascular risk factors and the risk for cardiovascular events in a Caucasian population with polycystic ovary syndrome
Authors' conclusion
Caucasian patients with PCOS do not have an increased risk for CV events during the late reproductive or early post-menopausal period, despite the increase in most CV risk factors, except for EFT that markedly decreases. Further studies are needed to determine the role of EFT on CV risk in PCOS.
Study context
- Population
- Caucasian women of reproductive age with polycystic ovary syndrome (PCOS) (National Institutes of Health criteria), assessed 2009 and 2020; mean age at follow-up 51.9 ± 7.7 yearsmatched cohort
- Participants
- 120 vs 600
- Exposure
- PCOS vs matched controls
- PCOSn = 120
- Controlsn = 600reference
- Outcome
- Risk of CV events:
- Major
- Minor
- Follow-up
- 10 years
Methodological detailsmatched by age and presence/absence of T2D, 5 controls per patient, 10 years of follow-up
- Matched by age and presence/absence of T2D
- 5 controls per patient
- 10 years of follow-up
Main finding
As reported in the abstract
CV events · 10 years
Major cardiovascular (CV) events, PCOS vs controls
0% vs. 2%
Any minor CV events, PCOS vs controls
4.2% vs. 2.3%
Observational data: associations, not effects.
Further findings
CV risk factors over follow-up in PCOS · 2009 to 2020
- Percentage of most CV risk factors (obesity, T2D, hypertension, dyslipidaemia, carotid intima media thickness ≥1 mm with or without non-critical plaques) increased
- Short- and long-axis epicardial fat thickness (EFT) and smoking decreased markedly
Original publication
Evolution of cardiovascular risk factors and the risk for cardiovascular events in a Caucasian population with polycystic ovary syndrome. Eur J Endocrinol. Published 28 February 2025. doi:10.
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