Evaluating the incidence of complications among people with diabetes according to age of onset: Findings from the UK Biobank
Authors' conclusion
Our study indicates age at diagnosis of diabetes does not significantly impact the incidence of complications, independently of the duration of diabetes. Instead, complications are primarily influenced by current age and diabetes duration.
Study context
- Population
- People with T2D in the UK Biobank; mean age at baseline 60.2 years
- Participants
- 19,327 people
- Exposure
- Younger-onset T2D (diagnosed <40 years) vs later-onset T2D (diagnosed ≥40 years), by current age, age at diagnosis and diabetes duration
- Outcome
- Incidence rates of complications: MI, HF, stroke, ESKD, CKD, liver diseases, depression and anxiety
- Follow-up
- Median 13.9 years
Methodological detailsPoisson regression
- Poisson regression
Main finding
As reported in the abstract
Incidence of complications by age at onset
- No clear evidence of an effect of age of onset on risk of complications after accounting for current age and diabetes duration
- Incidence of myocardial infarction (MI), heart failure (HF), stroke and chronic kidney diseases (CKD) strongly positively associated with age and diabetes duration
- Incidence of end-stage kidney diseases (ESKD), liver diseases and anxiety mainly depended on diabetes duration
- Incidence of depression showed minor variation by age and duration; highest among those diagnosed at earlier ages
Observational data: associations, not effects.
Further findings
Diabetes duration
Diabetes duration
- Diabetes duration significantly longer in younger-onset T2D
Original publication
Evaluating the incidence of complications among people with diabetes according to age of onset: Findings from the UK Biobank. Diabet Med. Published 29 May 2024. doi:10.
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