Evaluating the prognostic performance of bedside tests used for peripheral arterial disease diagnosis in the prediction of diabetic foot ulcer healing
Authors' conclusion
No single test performed well enough to be used in isolation as a prognostic marker for the prediction of DFU healing.
Study context
- Population
- TrEAD participants with diabetic foot ulceration (DFU)
- Participants
- 123 participants
- Comparison
- Bedside tests for peripheral arterial disease (PAD) diagnosis in prediction of DFU healing
- Primary endpoint
- Sensitivity for predicting ulcer healing
- Follow-up
- 12 months
Methodological details12-month follow-up
- 12-month follow-up
Primary result
As reported in the abstract
Prognostic performance for DFU healing
Ulcers healed
52.8%
Best negative diagnostic likelihood ratio: Podiatry ankle duplex scan (PAD-scan) monophasic or biphasic with adverse features
NDLR 0.35, 95% CI 0.14-0.90
Positive diagnostic likelihood ratio (PDLR), TBPI ≤0.2
7.67, 95% CI 0.91-64.84
PDLR, TcPO2 ≤20 mm Hg
2.68, 95% CI 0.54-13.25
Secondary outcomes
Probability of healing by PAD-scan waveform (Cox proportional hazards)
- Triphasic waveforms, HR
- 2.54, 95% CI 1.23-5.3, p=0.012
- Biphasic waveforms with non-adverse features, HR
- 13.67, 95% CI 4.78-39.1, p<0.001
Original publication
Evaluating the prognostic performance of bedside tests used for peripheral arterial disease diagnosis in the prediction of diabetic foot ulcer healing. BMJ Open Diabetes Res Care. Published 14 March 2023. doi:10.
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