European clinical guidance for the management of adrenal and extra-adrenal paraganglioma in children and adolescents: a consensus by the EXPeRT group
Methodological detailsconsensus statement, structured consensus, multidisciplinary expert panel, simplified GRADE system
- Consensus statement
- Structured consensus
- Multidisciplinary expert panel
- Simplified GRADE system
Recommendations
As issued by the authors
Diagnosis based on plasma-free metanephrine and normetanephrine as first-line test, complemented by anatomical and functional imaging guided by biochemical phenotype and genotype
Germline genetic testing is recommended
Tumor resection remains the mainstay of curative treatment; cortical-sparing adrenalectomy advised in bilateral hereditary cases (except SDHB)
Metastatic disease management individualized: radionuclide therapy, systemic treatments, focal therapies and palliative care as appropriate
Lifelong surveillance, tailored to genotype and disease characteristics
Original publication
European clinical guidance for the management of adrenal and extra-adrenal paraganglioma in children and adolescents: a consensus by the EXPeRT group. Eur J Endocrinol. Published 20 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →