Eucaloric High-fat Diet Effects on Reproductive Hormone Profiles: Mimicking Reprometabolic Syndrome in Normal Weight Women
Authors' conclusion
Consumption of a 1-month HFD was sufficient to induce a significant and sustained reduction in LH and FSH and lower E1c and Pdg characteristic of reprometabolic syndrome of obesity in normal-weight, eumenorrheic women. This indicates that dietary intervention may be an effective strategy to mitigate reproductive hormone deficiencies in women with obesity-related subfertility.
Study context
- Population
- Healthy, eumenorrheic women with normal body mass index (BMI) (18–24.9 kg/m²), age 29.1 ± 6.3; university medical center
- Participants
- 18 participants
- Comparison
- During and after eucaloric high-fat diet (HFD) vs pre-diet
- Outcome
- Daily urinary LH, FSH, E1c and Pdg levels; peak and integrated hormone levels compared across cycles
- Follow-up
- 4 menstrual cycles: pre-diet, on-diet, 2 post-diet
Methodological detailssingle-group pre-post
- Single-group pre-post
Main finding
As reported in the abstract
Peak E1c, Pdg, FSH and LH · during and after HFD
- Peak estrone conjugate (E1c), Pdg, FSH and LH significantly lower during and after HFD vs pre-diet
- On-diet vs Pre-diet: P < 0.05
- Post-diet vs Pre-diet: P < 0.05
Further findings
| Outcome | P value |
|---|---|
| Luteal phase urinary FSH and LH (AUC) · post-dietPost-diet vs Pre-diet · lower post-diet | P < 0.01 |
Menstrual cycle length
- No significant changes in menstrual cycle length
Weight and BMI
- Participants weight-stable with no change in BMI
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Eucaloric High-fat Diet Effects on Reproductive Hormone Profiles: Mimicking Reprometabolic Syndrome in Normal Weight Women. J Clin Endocrinol Metab. Published 6 November 2025. doi:10.
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