Ethnic differences in the association between age at diagnosis of diabetes and the risk of cardiovascular complications: a population-based cohort study
Authors' conclusion
There are important ethnic differences in the association between age at diagnosis and risk of cardiovascular complications.
Study context
- Population
- Individuals with diabetes (49.7% women) and matched individuals without diabetes, Ontario, Canada (2002–18); Chinese, South Asian and general population453,433 with diabetes
- Exposure
- Young-onset vs usual-onset diabetes vs ethnicity-matched individuals without diabetes, by ethnicity (Chinese, South Asian, general population)
- Matchesn = 453,433reference
- Outcome
- Cardiovascular complications
Methodological detailsmatched individuals without diabetes
- Matched individuals without diabetes
Main finding
As reported in the abstract
Cardiovascular risk vs ethnicity-matched individuals without diabetes, by age at diagnosis and ethnicity
Each group vs matchesEstimate (CI)
Young-onset diabetes
HR (Chinese) 4.25(3.05–5.91)
Young-onset diabetes
HR (South Asian) 3.82(3.19–4.57)
Young-onset diabetes
HR (General) 3.46(3.26–3.66)
Usual-onset diabetes
HR (Chinese) 2.22(2.04–2.66)
Usual-onset diabetes
HR (South Asian) 2.43(2.22–2.66)
Usual-onset diabetes
HR (General) 1.83(1.81–1.86)
- Interaction between age at diagnosis and ethnicity
- P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Young-onset diabetes: cardiovascular risk by ethnicity vs general populationChinesevs General population | HR, overall cardiovascular 0.44 (CI 0.32–0.61) | |
| Young-onset diabetes: cardiovascular risk by ethnicity vs general populationSouth Asianvs General population | HR, overall cardiovascular 0.75 (CI 0.64–0.89) | |
| Usual-onset diabetes: cardiovascular risk by ethnicity vs general populationChinesevs General population | HR, cardiovascular 0.44 (CI 0.42–0.46) | |
| Usual-onset diabetes: cardiovascular risk by ethnicity vs general populationSouth Asianvs General population | HR, cardiovascular 0.90 (CI 0.86–0.95) | |
| Usual-onset diabetes: cardiovascular risk by ethnicity vs general populationSouth Asianvs General population | HR, coronary artery disease 1.08 (CI 1.01–1.15) | |
| 0.20.5125Ratio (log scale) |
Young-onset diabetes: cardiovascular risk by ethnicity vs general population
- Chinese: similar stroke risk vs general population
- South Asian: similar coronary artery disease risk vs general population
Original publication
Ethnic differences in the association between age at diagnosis of diabetes and the risk of cardiovascular complications: a population-based cohort study. Cardiovasc Diabetol. Published 4 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →