ERRγ1 and Aromatase Expression in Human Placental Tissues from Term Deliveries of Large for Gestational Age Newborns
Authors' conclusion
High expression of ERRγ1 as well as ActAro/TotalAro ratio in LGA suggests that ERRγ1 is involved in ActAro variant expression and hence disrupted estrogen-androgen balance in the intrauterine environment. We propose that dysregulation of ERRγ1 in the placenta might modify the estrogen-androgen balance in the intrauterine environment in LGA newborns, possibly representing one of the key factors in the regulation of fetal programming.
Study context
- Population
- Placental tissues from term deliveries of large for gestational age (LGA) and adequate for gestational age (AGA) newborns
- Participants
- 8 vs 10
- Comparison
- Placental tissue of LGA vs AGA newborns
- LGAn = 8
- AGAn = 10reference
- Outcome
- ERRγ1 and aromatase mRNA in human placenta
Methodological detailsERRγ1 and aromatase mRNA variants analysed by RT2-PCR; aromatase protein by Western blot
- ERRγ1 and aromatase mRNA variants analysed by RT2-PCR; aromatase protein by Western blot
Main finding
As reported in the abstract
- ERRγ1 mRNA significantly higher in LGA vs AGA
- TotalAro mRNA significantly lower in LGA vs AGA
- Aromatase protein: similar results (lower in LGA)
- Active aromatase (ActAro)/TotalAro ratio higher in LGA vs AGA
Observational data: associations, not effects.
Original publication
ERRγ1 and Aromatase Expression in Human Placental Tissues from Term Deliveries of Large for Gestational Age Newborns. Horm Res Paediatr. Published 26 March 2024. doi:10.
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