Epicardial adipose tissue volume and density are associated with heart failure with improved ejection fraction
Authors' conclusion
This study reveals that lower EAT volume and higher EAT density are associated with development of HFimpEF. Therapies targeted at reducing EAT quantity and improving its quality might provide favorable effects on myocardial recovery in HF patients.
Study context
- Population
- Hospitalized heart failure (HF) patients with reduced ejection fraction (EF) (LVEF ≤ 40%) who underwent coronary CT angiography during index hospitalization, November 2011–December 2022
- Participants
- 203 patients
- Exposure
- HFimpEF vs persistent HFrEF, by epicardial adipose tissue (EAT) volume and density
- HFimpEFn = 104
- Outcome
- Incidence of HFimpEF and its relation to EAT volume and density
- Follow-up
- Median 8.6 (4.9 ≈13.3) months
Methodological detailsconsecutively enrolled, hospitalized HFrEF patients
- Consecutively enrolled
- Hospitalized HFrEF patients
Main finding
As reported in the abstract
median follow-up 8.6 months
Odds ratio (95% CI)
Lower EAT volume
0.885(0.822 ≈0.947)
Higher EAT density
1.845(1.023 ≈3.437)
- Developed HFimpEF
- 104 (51.2%)
Observational data: associations, not effects.
Further findings
EAT volume · lower with HFimpEF
P < 0.001
| Outcome | HFimpEF | HFrEF | P value |
|---|---|---|---|
| EAT densityHigher with HFimpEF | −74.92 ± 6.84 HU | −78.76 ± 6.28 HU | P < 0.001 |
Subgroups by HF etiology
- Association between EAT properties and HFimpEF not modified by HF etiology
Original publication
Epicardial adipose tissue volume and density are associated with heart failure with improved ejection fraction. Cardiovasc Diabetol. Published 3 August 2024. doi:10.
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