Association of triglyceride-glucose index with the risk of incident aortic dissection and aneurysm: a large-scale prospective cohort study in UK Biobank
Authors' conclusion
TyG index is independently associated with a higher risk of incident AD/AA, indicating the importance of using TyG index for risk assessment of AD/AA, especially for AA.
Study context
- Population
- Participants without baseline aortic dissection (AD) or aortic aneurysm (AA), UK Biobank cohort3,481 AD/AA cases
- Participants
- 420,292 participants
- Exposure
- Triglyceride-glucose (TyG) index quartiles
- Outcome
- Incident AD/AA, comprising AD and AA
- Follow-up
- Median 14.8 (14.1, 15.5) years
Methodological detailslarge-scale, UK Biobank, multivariable-adjusted Cox proportional hazards regression, restricted cubic spline analyses
- Large-scale
- UK Biobank
- Multivariable-adjusted Cox proportional hazards regression
- Restricted cubic spline analyses
Main finding
As reported in the abstract
Incident AD/AA · median 14.8 years
Each group vs reference quartileAdjusted hazard ratio (95% CI)
Quartile 2
1.20(1.08–1.35)
Quartile 3
1.21(1.08–1.35)
Quartile 4
1.30(1.16–1.45)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Incident AAQuartile 4vs Reference quartileHighest TyG index quartile had highest risk of AA | 1.35 (1.20–1.52) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Association of triglyceride-glucose index with the risk of incident aortic dissection and aneurysm: a large-scale prospective cohort study in UK Biobank. Cardiovasc Diabetol. Published 2 August 2024. doi:10.
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