Epicardial adipose tissue density is a better predictor of cardiometabolic risk in heart failure with preserved ejection fraction (HFpEF) patients: a prospective cohort study
Authors' conclusion
EAT density was an independent impact factor of cardiometabolic risk in HFpEF. EAT density might have better predictive value than EAT volume for metabolic syndrome and it might have prognostic value in patients with HFpEF.
Study context
- Population
- HFpEF patients who underwent noncontrast cardiac computed tomography (CT), all followed up
- Participants
- 154 patients
- Exposure
- Associations of epicardial adipose tissue (EAT) density (per 1 HU increase) with cardiometabolic risk factors, metabolic syndrome and outcomes
- Outcome
- Cardiometabolic risk factors per 1 HU increase in EAT density
Main finding
As reported in the abstract
- BMI lower
- 0.14 kg/m² (95% CI 0.08-0.21)
- Waist circumference lower
- 0.34 cm (95% CI 0.12-0.55)
- Non-HDL-cholesterol lower
- 0.02 mmol/L (95% CI 0-0.04)
- TG lower
- 0.03 mmol/L (95% CI 0.01-0.04)
- FPG lower
- 0.05 mmol/L (95% CI 0.02-0.08)
- TyG index lower
- 0.03 (95% CI 0.02-0.04)
- Log2(TG/HDL-C) lower
- 0.03 (95% CI 0.02-0.05)
- METS-IR lower
- 0.36 (95% CI 0.23-0.49)
- MetS Z-score lower
- 0.04 (95% CI 0.02-0.06)
- Log2(CACS + 1) lower
- 0.09 (95% CI 0.02-0.15)
Observational data: associations, not effects.
Further findings
AUC for presence of metabolic syndrome: EAT density vs volume
- AUC EAT density vs volume
- 0.731 vs 0.694
AUC for severity of metabolic syndrome: EAT density vs volume
- AUC EAT density vs volume
- 0.735 vs 0.662
HF readmission and composite endpoint · median follow-up 16 months
- Cumulative incidence of HF readmission and composite endpoint increased with lower EAT density
- both p < 0.05
Original publication
Epicardial adipose tissue density is a better predictor of cardiometabolic risk in HFpEF patients: a prospective cohort study. Cardiovasc Diabetol. Published 4 March 2023. doi:10.
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