Environmental Phenols and Growth in Infancy: The Infant Feeding and Early Development Study
Authors' conclusion
Early phenol exposure was associated with a higher mean and rapid increase in BMI z-score across infancy, signaling potential long-term cardiometabolic consequences of exposure.
Study context
- Population
- Infants in a prospective US-based cohort, 2010–2014; 7 urinary phenols measured at ages 6–8 and 12 weeks
- Participants
- 199 infants
- Exposure
- Early infancy urinary phenol exposure and body mass index (BMI) z-score level and trajectories
- Outcome
- Level of BMI z-score (mean differences) and BMI z-score trajectories (RR)
- Follow-up
- Up to 12 visits between birth and 36 weeks
Methodological detailsUS-based
- US-based
Main finding
As reported in the abstract
Mean BMI z-score (mean difference, β [95% CI]) · birth to 36 weeks
Benzophenone-3
0.07
−0.05, 0.18
Methyl paraben
0.10
−0.08, 0.27
Propyl paraben
0.08
−0.09, 0.25
All phenols jointly
0.17
−0.08, 0.43
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| Rapid increase BMI z-score trajectory (vs stable trajectory), per averaged early infancy phenol exposure · birth to 36 weeksBenzophenone-3 · relative to a stable trajectory | 1.46 (0.89–2.39) | |
| Rapid increase BMI z-score trajectory (vs stable trajectory), per averaged early infancy phenol exposure · birth to 36 weeksAll phenols jointly · relative to a stable trajectory | 1.41 (0.71–2.84) | |
| 0.20.5125Relative risk (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Environmental Phenols and Growth in Infancy: The Infant Feeding and Early Development Study. J Clin Endocrinol Metab. Published 16 May 2024. doi:10.
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