Enhancing Angioinvasion Assessment in Papillary Thyroid Cancer Via a Biomarker Panel Involving TAC, 8-OHdG, and Sortilin
Authors' conclusion
Measuring TAC, 8-OHdG, and sortilin levels may serve as potential biomarkers for identifying angioinvasion in PTC. The combined assessment of these biomarkers enhances angioinvasion discernment, aiding risk stratification and personalized treatment decisions. Further validation studies are required before integrating these biomarkers into routine clinical practice. The study adheres to the provided structure, providing concise and supported conclusions based on the results.
Study context
- Population
- Patients with Papillary Thyroid Cancer (PTC), Department of Endocrinology, Diabetology, and Internal Diseases, Medical University of Bialystok, Poland
- Participants
- 50 vs 30
- Exposure
- Angioinvasive PTC vs PTC with low-risk features
- Studyn = 50
- Referencen = 30reference
- Outcome
- Serum levels of 8-OHdG, total oxidative capacity, TAC and sortilin
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Serum 8-OHdG, sortilin and TAC
Regression panel combining TAC, 8-OHdG and sortilin: AUC for angioinvasion discernment
0.963
Observational data: associations, not effects.
Original publication
Enhancing Angioinvasion Assessment in Papillary Thyroid Cancer Via a Biomarker Panel Involving TAC, 8-OHdG, and Sortilin. J Clin Endocrinol Metab. Published 5 January 2024. doi:10.
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