Enhanced Weight Management Program for Veterans With Posttraumatic Stress Disorder: A Randomized Clinical Trial
Authors' conclusion
In this randomized clinical trial, weight change did not differ between a tailored weight management program for veterans with PTSD (MOVE!+UP) and VHA's standard weight management program (MOVE!). These results suggest that research must continue to address weight loss among those with PTSD.
Study context
- Population
- Veterans with posttraumatic stress disorder (PTSD) and BMI ≥25 engaged in PTSD care, 1 VHA site; mean age 55 years, 65% menrandomized
- Participants
- 174 veterans
- Comparison
- MOVE!+UP vs MOVE!
- Primary endpoint
- Weight change measured on a study-provided scale
- Follow-up
- 6 months
Methodological detailssingle-centre, masked outcome assessors
- Single-centre
- Masked outcome assessors
Primary result
Weight loss
Adjusted mean weight change difference
−1.5 lb
95% CI −5.9 to 2.9
P = 0.50
By group
Between MOVE!+UP and MOVE!
adjusted mean weight change difference −1.5 lb (95% CI −5.9 to 2.9); P = 0.50
As reported in the abstract
Secondary outcomes
Change in PTSD symptoms at 6 and 12 months; weight change at 12 months
- Did not significantly differ between groups
Safety
Withdrawals due to adverse events
- Participants withdrawn due to adverse events
- 0
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Enhanced Weight Management Program for Veterans With Posttraumatic Stress Disorder: A Randomized Clinical Trial. JAMA Netw Open. Published 2 March 2026. doi:10.
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