Endothelial Function Is Associated With Incident Diabetes Mellitus: The ELSA ‐Brasil Cohort Study
Authors' conclusion
Impaired endothelial function at baseline was independently associated with incident diabetes in Brazilian adults, regardless of obesity.
Study context
- Population
- Brazilian adults from the ELSA-Brasil cohort without DM at baseline and with valid endothelial function measurements; mean age 51 ± 8 years, 45% women, mean body mass index (BMI) 26.4 ± 4.4 kg/m²159 developed DM
- Participants
- 1,268 adults
- Exposure
- Impaired vs better microvascular endothelial function
- Outcome
- Incident DM
- Follow-up
- Mean 8.8 years (SD = 2.1)
Methodological detailssex-specific quartiles, multivariable Cox proportional hazards models
- Sex-specific quartiles
- Multivariable Cox proportional hazards models
Main finding
As reported in the abstract
Incident diabetes by endothelial function (sex-specific quartiles)
Hazard ratio (95% CI)
Impaired endothelial function (BPA)multivariable adjusted
2.13(1.24–3.66)
PAT ratiomultivariable adjusted; weaker association
1.54(0.90–2.60)
Observational data: associations, not effects.
Further findings
- No effect modification by obesity status was observed
Original publication
Endothelial Function Is Associated With Incident Diabetes Mellitus: The ELSA ‐Brasil Cohort Study. Diabetes Obes Metab. Published 16 June 2026. doi:10.
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