Bisphenol A decreases peripheral insulin sensitivity in normal weight adults: a double-blind randomized controlled trial
Authors' conclusion
BPA administration decreased peripheral insulin sensitivity after 5 days.
Study context
- Population
- Sedentary but otherwise healthy normal weight adults (22 F, 18 M; 21.3 ± 2.1 year; 22.1 ± 2.3 kg/m²; 85% non-Hispanic White)
- Participants
- 40 adults
- Comparison
- Oral Bisphenol A (BPA) 50 µg/kg body weight vs placebo for 5 days
- Primary endpoint
- Peripheral insulin sensitivity via 120-minute euglycemic hyperinsulinemic clamp
- Follow-up
- 5 days
Methodological detailsdouble-blind
- Double-blind
Primary result
As reported in the abstract
Change in peripheral insulin sensitivity · after 5 days
| Group | Value | Direction |
|---|---|---|
| BPA-50 | 0.02 ± 0.01 mg/kg/min/uU/mL | decrease |
| Placebo (PL) | 0.02 ± 0.01 mg/kg/min/uU/mL | increase |
Value
BPA-500.02 ± 0.01 mg/kg/min/uU/mL
Placebo (PL)0.02 ± 0.01 mg/kg/min/uU/mL
Direction
BPA-50decrease
Placebo (PL)increase
- BPA-50 vs PL: P = 0.01
Further findings
| Outcome | BPA-50 | PL | P value |
|---|---|---|---|
| Change in urine BPA · after treatment | + 268 700 ± 63 983 pg/mL | + 8893 ± 6786 pg/mL | P = 0.009 |
- Body weight and fasting glucose · after treatment
- P > 0.05
Body weight and fasting glucose · after treatment
- Body weight and fasting glucose not statistically different between PL and BPA-50
Original publication
Bisphenol A decreases peripheral insulin sensitivity in normal weight adults: a double-blind randomized controlled trial. J Clin Endocrinol Metab. Published 20 March 2026. doi:10.
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