Endothelial and exercise vasodilation are reduced in postmenopausal females with obesity versus lean and overweight
Authors' conclusion
Postmenopausal females with OB have reduced lower-limb endothelial and exercise vasodilator function during submaximal dynamic plantarflexion exercise compared to LN and OW. Our findings indicate that obesity may predict diminished leg endothelial function, BF and VC during exercise in postmenopausal females.
Study context
- Population
- Postmenopausal females grouped by body mass index (BMI) into lean, overweight and obese categories
- Participants
- 11 / 15 / 13
- Exposure
- Obesity (OB) vs lean (LN) and overweight (OW) postmenopausal females
- LNn = 11reference
- OWn = 15
- OBn = 13
- Outcome
- FA-FMD and BA-FMD
Main finding
As reported in the abstract
- No differences in BA-FMD between groups
- OB vs LN: P < 0.05
- OB vs OW: P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| FA-BF and FA-VC during last stage of plantarflexion exercise at 30% of 1RMOB vs LN and OW | P < 0.001 |
- FA-BF and FA-VC during last stage of plantarflexion exercise at 30% of 1RM: Increases in FA-BF and FA-VC attenuated in OB (both P < 0.001)
FA-BF and FA-VC during last stage of plantarflexion exercise at 30% of 1RM
- Upper-body exercise vasodilation unchanged
Correlations of FA-BF and FA-VC during plantarflexion exercise with FA-FMD and BMI
- FA-BF vs FA-FMD
- r = 0.423, P = 0.007
- FA-VC vs FA-FMD
- r = 0.367, P = 0.021
- FA-BF vs BMI
- r = −0.386, P = 0.015
- FA-VC vs BMI
- r = −0.456, P = 0.004
Original publication
Endothelial and exercise vasodilation are reduced in postmenopausal females with obesity versus lean and overweight. Int J Obes (Lond). Published 17 January 2024. doi:10.
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