Endogenous Glucose Production in Patients With Glycogen Storage Disease Type Ia Estimated by Oral D-[6,6-2H2]-glucose
Study context
- Population
- Adults with GSDIa and age-, sex- and BMI-matched healthy volunteers (HVs)
- Participants
- 10 vs 10
- Comparison
- Patients with GSDIa vs matched healthy volunteers
- GSDIan = 10
- HVsn = 10reference
- Outcome
- Rate of appearance of endogenous glucose into the bloodstream (Ra) after a single oral stable-isotope glucose tracer dose
Methodological detailsage-, sex-, and BMI-matched healthy volunteers, stable isotope tracer
- Age-, sex-, and BMI-matched healthy volunteers
- Stable isotope tracer
Main finding
As reported in the abstract
Time-averaged glucose Ra
- Time-averaged glucose Ra significantly higher in postprandial vs fasted HVs
- P < .05
- Progressive decrease in glucose Ra in preprandial/fasted GSDIa; change in Ra time-course directly correlated with change in capillary glucose
- P < .05
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Endogenous Glucose Production in Patients With Glycogen Storage Disease Type Ia Estimated by Oral D-[6,6-2H2]-glucose. J Clin Endocrinol Metab. Published 10 September 2023. doi:10.
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