The Rising Incidence of Hyperinsulinemic Hypoglycemia: Connection With Maternal Health
Authors' conclusion
While HH diagnoses were on the rise for much of the 9-year study period, nearly half of all infants were diagnosed during the COVID-19 pandemic in 2020 to 21. The trends in HH diagnoses correlated with maternal hypertensive disorders. More studies exploring the roles of maternal health, hypertension, and stress and development of HH in offspring are needed.
Study context
- Population
- Children diagnosed with hyperinsulinemic hypoglycemia (HH) and evaluated by Pediatric Endocrinology, 2013–2021over 9 years
- Participants
- 74 children
- Outcome
- Trends in incidence of HH over time
- Follow-up
- 2013–2021
Methodological detailssingle-institution chart review, regression analysis of trends
- Single-institution chart review
- Regression analysis of trends
Main finding
As reported in the abstract
Incidence of HH over time
- Incidence of HH began to rise in April 2016 and became significant in March 2017
- P < .001
- More rapid rate of rise during the first year of the COVID-19 pandemic
- P < .001
- Children with HH diagnosed in 2020-2021
- 43% (n = 32)
Observational data: associations, not effects.
Further findings
Maternal hypertensive disorders and HH cases
- Maternal hypertensive disorders showed longitudinal association with hyperinsulinism cases
- P < 0.001
Original publication
The Rising Incidence of Hyperinsulinemic Hypoglycemia: Connection With Maternal Health. Endocr Pract. Published 7 September 2023. doi:10.
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