Emergency Hospitalization, Amputation, and Survival After Charcot Neuro-Osteoarthropathy Diagnosis in People With Diabetes: A Regional Registry-Based Cohort Study
Authors' conclusion
Adverse outcomes in CNO were frequent and occurred early after diagnosis, with high rates of emergency hospitalization, amputation, and death.
Study context
- Population
- Adults with diabetes and a first recorded Charcot neuro-osteoarthropathy (CNO) diagnosis, NHS Greater Glasgow and Clyde, Scotland (2015–2024); mean age 59 years, 67% menfrom 127,513 adults with DM
- Participants
- 140 adults
- Outcome
- Adverse outcomes after CNO diagnosis
- Follow-up
- median 4.6-year follow-up
Methodological detailsregional, registry-based, linked routinely collected health care data
- Regional
- Registry-based
- Linked routinely collected health care data
Main finding
As reported in the abstract
- Emergency admission
- 123 (87.9%)
- Lower-extremity amputation (minor or major)
- 44 (31.4%)
- Died
- 53 (37.9%)
- Estimated 5-year survival
- 67%
- 5-year amputation-free survival
- 44% (median 4.04 years)
Observational data: associations, not effects.
Further findings
Associations with clinical characteristics
| Estimate | ||
|---|---|---|
| High or active foot-risk statusIndependently associated | subdistribution HR for lower-extremity amputation 8.52 (95% CI 2.05–35.45) | |
| High or active foot-risk statusIndependently associated | HR for shorter amputation-free survival 2.09 (95% CI 1.15–3.80) | |
| Older ageIndependently associated | HR for mortality 3.04 (95% CI 1.50–6.16) | |
| 0.050.21520Ratio (log scale) |
- Advanced CKD (stages 4 and 5) was associated with higher risk across outcomes
Original publication
Emergency Hospitalization, Amputation, and Survival After Charcot Neuro-Osteoarthropathy Diagnosis in People With Diabetes: A Regional Registry-Based Cohort Study. Diabetes Care. Published 28 July 2026. doi:10.
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