Elevated serum glucosylsphingosine level in children with obesity: relation to plasma atherogenesis
Authors' conclusion
Serum Lyso-GL-1 is elevated in children with obesity, being closely correlated with hypertension, insulin resistance, and atherogenesis. This could provide a mechanistic insight on the role of Lyso-GL-1 in obesity and atherogenesis. Further studies are warranted to explore the potential role of Lyso-GL-1 as a biomarker and target for the prevention and treatment of obesity-related atherogenesis and insulin resistance.
Study context
- Population
- Children with obesity, mean age 10.06 years (SDS ± 2.22), and age- and sex-matched normal-weight controls
- Participants
- 60 vs 60
- Comparison
- Children with obesity vs normal-weight controls
- Obesityn = 60
- Controlsn = 60reference
- Outcome
- Serum Lyso-GL-1 level and its correlation with biomarkers of insulin resistance and AIP
Methodological detailsage- and sex-matched controls
- Age- and sex-matched controls
Main finding
As reported in the abstract
Serum Lyso-GL-1 and AIP
- Lyso-GL-1 significantly positively correlated with body mass index (BMI) z-score, waist/hip ratio z-score, systolic and diastolic BP percentiles, LDL-C, homeostatic model assessment of insulin resistance (HOMA-IR) and atherogenic index of plasma (AIP)
- p < 0.05
Observational data: associations, not effects.
Original publication
Elevated serum glucosylsphingosine level in children with obesity: relation to plasma atherogenesis. Int J Obes (Lond). Published 22 January 2026. doi:10.
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