Brain Serotonin Transporter Is Elevated in Obesity: Bayesian and Frequentist Meta‐Analyses
Pooled result · Brain SERT availabilityResult — go to the resultPooled SMD 0.2675 CrI 0.0075–0.5275Authors' conclusion
A modest elevation in brain SERT availability in subjects with obesity was supported by frequentist meta-analysis, but this finding was not conclusively supported by Bayesian hierarchical modelling.
Study context
- Population
- PET and SPECT studies comparing brain serotonin transporter (SERT) availability between obese and non-obese individuals5 studies
- Participants
- 142 vs 115
- Comparison
- Obese vs non-obese individuals
- Obesen = 142
- Non-obesen = 115reference
- Outcome
- Brain SERT availability
Methodological detailsfrequentist and Bayesian meta-analyses, meta-regression
- Frequentist and Bayesian meta-analyses
- Meta-regression
Pooled result
As reported in the abstract
Pooled SMD
0.2675
CrI 0.0075–0.5275
P = 0.0437
With obesityvs Without obesity
pooled SMD 0.2675 (CrI 0.0075–0.5275); P = 0.0437
Further pooled results
Moderators (studies, radiopharmaceuticals, regions of interest)
- No substantial differences across studies, radiopharmaceuticals and regions of interest
Original publication
Brain Serotonin Transporter Is Elevated in Obesity: Bayesian and Frequentist Meta‐Analyses. Diabetes Obes Metab. Published 21 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →