Elevated risk of infection in individuals with hyperinsulinaemic type 2 diabetes: a Danish 12 year cohort study
Authors' conclusion
The risk of severe infections is clearly elevated in individuals with type 2 diabetes characterised by a higher degree of insulin resistance/hyperinsulinaemia.
Study context
- Population
- Danish individuals with recently diagnosed T2D (median duration 1.4 years, IQR 0.5–2.9 years)
- Participants
- 7,265 individuals
- Exposure
- Hyperinsulinaemic and classical vs insulinopenic T2D
- Outcome
- First hospital-treated infection or first prescription for an anti-infective agent (community-treated infection)
Methodological detailsDanish, recently diagnosed T2D, Cox regression, adjusted HRs
- Danish
- Recently diagnosed T2D
- Cox regression, adjusted HRs
Main finding
As reported in the abstract
Hospital-treated infections · 10 year
Each group vs insulinopenicAdjusted hazard ratio (95% CI)
Hyperinsulinaemic
1.38(1.16–1.65)
Classical
1.20(1.02–1.42)
Observational data: associations, not effects.
Further findings
| Outcome | Hyperinsulinaemic | Classical | Insulinopenic | aHR (95% CI) | |
|---|---|---|---|---|---|
| Community-treated infections · 10 yearHyperinsulinaemicvs Insulinopenic | 91.6% | 90.1% | 88.3% | 1.20 (1.08–1.33) | |
| Community-treated infections · 10 yearClassicalvs Insulinopenic | 1.10 (1.00–1.21) | ||||
| 0.512Adjusted hazard ratio (log scale) |
Further adjustment for abdominal obesity, metabolic derangements and low-grade inflammation
- Infection risk in the hyperinsulinaemic subgroup decreased substantially
Original publication
Elevated risk of infection in individuals with hyperinsulinaemic type 2 diabetes: a Danish 12 year cohort study. Diabetologia. Published 11 December 2024. doi:10.
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