Elevated high-sensitivity C-reactive protein levels increase the risk of new-onset cardiac conduction disorders
Authors' conclusion
High hsCRP levels are an independent risk factor for cardiac conduction disorders, and hsCRP levels are dose-dependently associated with the risk of conduction disorders. Our study results may provide new strategies for preventing cardiac conduction disorders.
Study context
- Population
- Community-based cohort; mean age 50.57 ± 11.88 years
- Participants
- 86,234 participants
- Exposure
- High-sensitivity C-reactive protein (hsCRP) > 3 mg/L vs hsCRP ≤ 3 mg/L
- Outcome
- New-onset cardiac conduction disorders (atrioventricular block, left and right bundle branch block)
Methodological detailsmultivariate Cox proportional hazard model
- Multivariate Cox proportional hazard model
Main finding
As reported in the abstract
Cardiac conduction disorders
Each group vs hsCRP ≤ 3 mg/LEstimate (95% CI)
hsCRP > 3 mg/L
HR (atrioventricular block) 1.64(1.44–1.87)
hsCRP > 3 mg/L
HR (left bundle branch block) 1.25(1.07–1.45)
hsCRP > 3 mg/L
HR (right bundle branch block) 1.31(1.17–1.47)
Observational data: associations, not effects.
Further findings
- Linear relationship between log (hsCRP) and risk (restricted cubic spline)
- All nonlinearity P > 0.05
- Risk of various cardiac conduction disorders increased per 1 SD increase in log (hsCRP)
Original publication
Elevated high-sensitivity C-reactive protein levels increase the risk of new-onset cardiac conduction disorders. Cardiovasc Diabetol. Published 30 September 2023. doi:10.
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