Temporal trends and outcomes of heart transplantation in Spain (2002–2021): propensity score matching analysis to compare patients with and without type 2 diabetes
Main finding · In-hospital mortality (Cox regression)Result — go to the resultHazard ratio 0.77 95% CI 0.63–0.98Authors' conclusion
The number of HTs increased in the period 2018-2021 compared with 2002-2005 in patients with and without T2D. Over time, complications of HT increased in both groups studied, whereas IHM decreased. The presence of T2D is associated with lower IHM.
Study context
- Population
- Heart transplantation (HT) recipients aged 35 and older, Spain, 2002–2021
- Participants
- 4,429 HTs
- Exposure
- HT recipients with T2D vs without T2D
- Outcome
- In-hospital mortality (IHM)
Methodological detailsnational hospital discharge database, propensity score matching, Cox regression
- National hospital discharge database
- Propensity score matching
- Cox regression
Main finding
In-hospital mortality (Cox regression)
Hazard ratio
0.77
95% CI 0.63–0.98
T2Dvs Without T2D
HR 0.77 (95% CI 0.63–0.98)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Number of HTs in patients with T2D · 2002–2021
- 2002-2005
- n = 171
- 2014-2017
- n = 154
- 2018-2021
- n = 186
Complications of HT over time · 2002-2005 vs 2018-2021
- T2D: 2002-2005 vs 2018-2021
- 26.9% vs 42.47%
- Without T2D: 2002-2005 vs 2018-2021
- 31.31% vs 45.01%
Infections, procedures and LOS after propensity score matching (PSM)
- Pneumonia and Gram-negative bacterial infections less frequent with T2D
- Hemodialysis, extracorporeal membrane oxygenation (ECMO) and tracheostomy less frequently required with T2D
- Shorter hospital stay with T2D
- Propensity score matching
Factors associated with in-hospital mortality (IHM) in T2D
- Hemodialysis and ECMO associated with IHM in T2D
- IHM decreased over time with and without T2D
Original publication
Temporal trends and outcomes of heart transplantation in Spain (2002–2021): propensity score matching analysis to compare patients with and without type 2 diabetes. Cardiovasc Diabetol. Published 29 September 2023. doi:10.
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