Elevated alanine transaminase is nonlinearly associated with in-hospital death in ICU-admitted diabetic ketoacidosis patients
Main finding · In-hospital death (unstratified cohort)Result — go to the resultHazard ratio 1.88 95 % CI 1.34–2.62Authors' conclusion
Elevated ALT is robustly associated with in-hospital death in ICU-admitted DKA patients across several subgroups. Close monitoring of ALT in these patients is recommended.
Study context
- Population
- Patients admitted to the ICU for diabetic ketoacidosis (DKA), eICU Collaborative Research Database
- Participants
- 2,684 patients
- Exposure
- Alanine transaminase (ALT) at 90th percentile vs median ALT
- Outcome
- In-hospital death
Methodological detailseICU Collaborative Research Database, Cox regression with restricted cubic splines, adjusted for multiple confounders
- eICU Collaborative Research Database
- Cox regression with restricted cubic splines
- Adjusted for multiple confounders
Main finding
In-hospital death (unstratified cohort)
Hazard ratio
1.88
95 % CI 1.34–2.62
90th percentile ALTvs Median ALT
HR 1.88 (95 % CI 1.34–2.62)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95 % CI) | |
|---|---|---|
| In-hospital death, subgroup: males | 1.69 (1.24–2.30) | |
| In-hospital death, subgroup: aged under 65 years | 1.65 (1.09–2.49) | |
| In-hospital death, subgroup: aged 65 years or above | 3.45 (1.67–7.14) | |
| In-hospital death, subgroup: non-obese | 1.52 (1.00–2.32) | |
| In-hospital death, subgroup: obese | 2.76 (1.38–5.54) | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Elevated alanine transaminase is nonlinearly associated with in-hospital death in ICU-admitted diabetic ketoacidosis patients. Diabetes Res Clin Pract. Published 3 February 2023. doi:10.
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