Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas
Authors' conclusion
These results suggest that severe insulin deficiency, rather than islet-directed autoimmunity, leads to reduced pancreas size in type 1 diabetes and that insulin is a major trophic factor for the exocrine pancreas.
Study context
- Population
- One family with an autosomal-dominant insulin gene mutation causing insulin deficiency similar in severity to T1D but without autoimmunity
- Participants
- 4 vs 4
- Comparison
- Family members with insulin gene mutation vs family members without diabetes
- Affected individualsn = 4
- Control family membersn = 4reference
- Outcome
- Pancreas volume and postprandial C-peptide
Methodological detailsfamily study, standardized MRI protocol
- Family study
- Standardized MRI protocol
Main finding
As reported in the abstract
- Markedly smaller pancreas in mutation carriers vs family members without diabetes
- Severely impaired postprandial C-peptide in mutation carriers vs family members without diabetes
Original publication
Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas. Diabetes Care. Published 1 February 2023. doi:10.
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