Efficacy and Safety of Meal Replacement in Patients With Type 2 Diabetes
Pooled result · HbA1cResult — go to the resultMD −0.46 %Authors' conclusion
Compared with CDs, the MR-based dietary pattern further improved the glycemic control and adipose indicators in T2D patients. Appropriate calorie restriction and total MR might be more beneficial, while both patients treated with or without insulin treatment could similarly benefit from MR usage.
Study context
- Population
- T2D patients in randomized controlled trials (RCTs) of ≥2 weeks; PubMed, CENTRAL, Embase, Web of Science and trial registry searched up to March 2022
- Participants
- 2,112 patients17 RCTs
- Comparison
- Meal replacement vs conventional diabetic diets
- Outcome
- HbA1c
Methodological detailssubgroup analyses of participant characteristics and meal replacement (MR) prescription
- Subgroup analyses of participant characteristics and MR prescription
Pooled result
As reported in the abstract
MD
−0.46 %
P < 0.001
Further pooled results
| Outcome | Estimate | P value |
|---|---|---|
| FBG | −0.62 mmol/L | P < 0.001 |
| Body weight | −2.43 kg | P < 0.001 |
| BMI | −0.65 | P < 0.001 |
Body mass index (BMI)
- MR improved other cardiometabolic risk factors
Subgroup: total vs partial MR (effect vs CDs)
- Hemoglobin A1c (HbA1c), total vs partial MR (P = .01)
- −0.72% vs −0.32%
- Fasting blood glucose (FBG), total vs partial MR (P = .02)
- −1.45 vs −0.56 mmol/L
- Body weight, total vs partial MR (P < .001)
- −6.57 vs −1.58 kg
- BMI, total vs partial MR (P < .001)
- −2.78 vs −0.37
- Total MR showed greater improvement than partial MR
Subgroup: MR with vs without caloric restriction
- Body weight, with vs without caloric restriction (P < .001)
- −3.20 vs −0.75 kg
- BMI, with vs without caloric restriction (P = .003)
- −0.84 vs −0.24
- MR with caloric restriction showed more reduction
Subgroup: insulin use
- MR showed similar benefits in studies with and without patients using insulin
Safety
Tolerability
- Both partial and total MR were well tolerated
Original publication
Efficacy and Safety of Meal Replacement in Patients With Type 2 Diabetes. J Clin Endocrinol Metab. Published 16 May 2023. doi:10.
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